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Related Experiment Video

Updated: May 12, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Anti-VEGF versus laser photocoagulation for ROP treatment.

Sanskriti Ukey¹, Shivam Pandey², Anjali Singh³

¹Department of Ophthalmology, NandKumar Singh Chauhan Medical college Khandwa, Madhya Pradesh, India.

|May 11, 2026

Summary

Intravitreal anti-VEGF therapy is effective for retinopathy of prematurity (ROP), offering high regression rates and preserving peripheral vision. Laser photocoagulation provides high initial success but ablates more retina, potentially increasing myopia risk.

Keywords:

Retinopathy of prematurity (ROP)anti-VEGF therapy laser photocoagulation

Related Experiment Videos

Last Updated: May 12, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Area of Science:

Ophthalmology
Neonatology
Vascular Biology

Background:

Retinopathy of prematurity (ROP) is a significant cause of infant blindness, particularly in premature infants.
ROP is a vascular disorder affecting the developing retina.

Purpose of the Study:

To compare the efficacy and outcomes of intravitreal anti-VEGF therapy versus laser photocoagulation for ROP treatment.
To evaluate treatment decisions based on ROP stage, zone, and risk-benefit analysis.

Main Methods:

Prospective comparative cohort study involving 1188 screened infants.
Treatment groups included intravitreal anti-VEGF (67 infants) and laser photocoagulation (10 infants).

Main Results:

Intravitreal anti-VEGF achieved 96.82% anatomical regression, with 3.17% requiring adjunctive laser.
Laser photocoagulation showed 100% primary anatomical success but ablates more peripheral retina.
Aggressive posterior ROP (APROP) responded well to anti-VEGF, though complications like cataract and retinal detachment occurred, necessitating follow-up.

Conclusions:

Anti-VEGF therapy is effective for Type 1 ROP, offering high regression rates and superior peripheral retinal sparing compared to laser.
Laser photocoagulation has high initial success but poses a greater risk of myopic shift.
Individualized treatment decisions considering zone, stage, and risk-benefit are crucial for optimal ROP management.