Dynamic changes in liquid biopsy markers during OSCC treatment: A longitudinal study.

Area of Science:

• Oncology
• Molecular Diagnostics
• Cancer Research

Background:

• Oral Squamous Cell Carcinoma (OSCC) frequently presents at advanced stages, resulting in poor patient prognosis and restricted therapeutic choices.
• Current diagnostic techniques for OSCC are invasive and do not offer real-time monitoring, highlighting a need for improved methods.

Purpose of the Study:

• To investigate the dynamic alterations of liquid biopsy markers during OSCC treatment.
• To assess the efficacy of these markers in monitoring treatment response and predicting survival outcomes in OSCC patients.

Main Methods:

• Analysis of dynamic changes in circulating tumor deoxyribonucleic acid (ctDNA), circulating tumor cells (CTCs), exosomes, and micro ribonucleic acids (microRNA) during OSCC therapy.
• Correlation of marker levels with treatment response and patient survival data.

Main Results:

• Dynamic changes in ctDNA, CTCs, exosomes, and microRNA effectively monitor treatment response in OSCC.
• These liquid biopsy markers demonstrate predictive value for survival outcomes in OSCC patients.

Conclusions:

• Liquid biopsies offer a non-invasive approach for personalized OSCC management.
• Monitoring liquid biopsy markers facilitates early detection of relapse in OSCC.