Dynamic changes in liquid biopsy markers during OSCC treatment: A longitudinal study

Oral Squamous Cell Carcinoma (OSCC) is often diagnosed at an advanced stage, leading to poor prognosis and limited treatment options. Traditional diagnostic methods are invasive and lack real-time monitoring capabilities. Therefore, it is of interest to investigate the dynamic changes in liquid biopsy markers circulating tumor deoxyribonucleic acid (ctDNA), circulating tumor cells (CTCs), exosomes and micro ribonucleic acids (microRNA) during OSCC treatment. Thus, we show that these markers can effectively monitor treatment response and predict survival outcomes. This research advances the knowledge of liquid biopsies as a non-invasive tool for personalized OSCC management and early relapse detection.