Comparative assessment of injectable platelet-rich fibrin versus concentrated growth factor for periodontal intrabony...

Periodontal intrabony defects present a therapeutic challenge and direct clinical evidence comparing injectable platelet-rich fibrin (i-PRF) and concentrated growth factor (CGF) as regenerative materials remains limited. This randomized controlled split-mouth clinical trial included 20 patients with 40 comparable three-wall intrabony defects treated by open flap debridement followed by either i-PRF or CGF, with clinical and radiographic parameters evaluated at baseline and 6 months. Both groups showed significant improvements in probing pocket depth, clinical attachment level and radiographic defect fill at 6 months (p<0.001). The CGF group demonstrated significantly greater pocket depth reduction, attachment gain and percentage of radiographic defect fill compared with the i-PRF group (p<0.05). Within the limitations of this study, both materials were effective, although CGF exhibited superior regenerative outcomes and may represent a more predictable option for periodontal intrabony defect regeneration.