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Published on: January 7, 2018
Preterm delivery and long-term maternal renal disease: A systematic review and meta-analysis
Emily Stocks1, Maryam Abdelkarim2,3, Megan Holness1
1Warwick Medical School, University of Warwick, Coventry, UK.
Objectives:
Little is known about the impact of premature delivery on maternal renal complications. This systematic review aimed to evaluate the association between earlier delivery and long-term renal health in the pregnant population.
Methods:
A comprehensive database search was performed. Eligible studies included cross-sectional and cohort studies that reported preterm and full-term deliveries and subsequent maternal chronic kidney disease. A random-effects meta-analysis was used to calculate the pooled effect estimates. The Newcastle-Ottawa scale was used to assess the risk of bias.
Results:
Nine studies met the inclusion criteria. Preterm delivery was associated with long-term maternal renal disease with a pooled odds ratio (OR = 1.82, 95% CI: 1.17-2.85, p = 0.01). A sensitivity analysis identifying outlier study, and the pooled OR excluding it (OR = 2.16, 95% CI, 2.06-2.62; p < 0. 001, I2 = 0.0%).
Conclusion:
Preterm delivery is associated with a significant risk of long-term maternal renal disease. This suggests the need for careful postnatal risk management in this population.
PréCis:
Preterm delivery is associated with higher risk of long-term maternal renal disease, warranting targeted postnatal care and further research into underlying biological mechanisms and preventive strategies.
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