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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma.

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Deep inspirations prior to oscillometry for detecting lung alterations in a mouse model of asthma: Yea or nay?

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Airway smooth muscle force adaptation on the methacholine response in asthmatic patients.

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Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma.

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Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo.

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Related Experiment Video

Updated: May 12, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

The testosterone paradox in asthma.

Ynuk Bossé1

  • 1Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) - Université Laval, Quebec, QC, Canada.

Frontiers in Allergy
|May 11, 2026
PubMed
Summary

Testosterone increases airway hyperresponsiveness to methacholine but protects against asthma. This

Area of Science:

  • Pulmonary Medicine and Endocrinology
  • Investigating the complex interplay between sex hormones and respiratory diseases.

Background:

  • Asthma is characterized by airway hyperresponsiveness (AHR) to stimuli like methacholine.
  • Testosterone, the primary male sex hormone, is known to increase AHR.

Purpose of the Study:

  • To explore the 'testosterone paradox', where testosterone increases AHR but exhibits protective effects in asthma.
  • To understand the mechanisms underlying testosterone's dual role in asthma and AHR.

Main Methods:

  • Review of existing literature on testosterone, AHR, and asthma.
  • Analysis of experimental models and clinical observations regarding testosterone's effects on the airways.

Main Results:

  • Testosterone administration demonstrably enhances methacholine-induced airway responses.
Keywords:
animal modelasthmahyperresponsivenessmethacholinerespiratory mechanics

Related Experiment Videos

Last Updated: May 12, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

  • Conversely, testosterone has shown protective effects in both human asthma and experimental asthma models.

    • Conclusions:

    • The observed protective role of testosterone in asthma contradicts its ability to increase AHR.
    • Further research is crucial to elucidate the specific molecular and cellular mechanisms driving the 'testosterone paradox' in respiratory health.