Related Experiment Video
Updated: May 12, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Corneal Topographic Changes and Intraocular Pressure in Different Stages of Obstructive Sleep Apnea: Case-Control
Mohammed Abdelmateen Moussa1, Enas T Zarief2, Mohammed M M Roushdy3
1Otorhinolaryngology Department, Sohag University, Sohag, Egypt.
Clinical Ophthalmology (Auckland, N.Z.)
|May 11, 2026
Summary
Obstructive sleep apnea (OSA) is linked to higher intraocular pressure and altered anterior chamber depth. Sleep fragmentation, indicated by arousal index, correlates with corneal changes, suggesting a connection between sleep quality and eye health.
Area of Science:
- Ophthalmology
- Sleep Medicine
- Medical Research
Background:
- Obstructive sleep apnea (OSA) is a prevalent condition with systemic health implications.
- Ocular changes associated with OSA are increasingly recognized.
- Understanding these changes can aid in early detection and management.
Purpose of the Study:
- To compare corneal topographic parameters and intraocular pressure (IOP) in patients with varying stages of OSA versus healthy controls.
- To investigate correlations between ocular findings and polysomnographic parameters in OSA patients.
Main Methods:
- A case-control study involving 55 OSA patients and 22 healthy controls.
- Ophthalmic assessments included Goldmann applanation tonometry for IOP and Scheimpflug-based corneal tomography.
- Corneal pachymetry, anterior chamber parameters, keratometric indices, and ectasia-related indices were analyzed.
Main Results:
- Anterior chamber depth was reduced in mild and severe OSA groups; anterior chamber volume was lowest in the mild OSA group.
- Intraocular pressure was significantly higher in moderate and severe OSA groups compared to controls.
- The arousal index correlated significantly with corneal pachymetry and progression indices.
Conclusions:
- Moderate to severe OSA is associated with elevated IOP and altered anterior chamber dimensions.
- Sleep fragmentation, measured by arousal index, shows a correlation with corneal structural changes.
- Further research with larger cohorts is warranted to validate these associations.
Related Concept Videos
01:21Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...