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Related Experiment Video

Updated: May 12, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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Published on: March 20, 2026

Glia-derived VCAM1 promotes glioma progression.

Jiajing Dai¹, Hailong Zheng¹, Jiaxu Luo¹

¹Department of Neurobiology, Basic Medical Sciences, Capital Medical University School, Beijing, China.

Frontiers in Oncology

|May 11, 2026

Summary

Astrocyte-derived VCAM1 drives glioma progression and impacts survival. Targeting VCAM1 offers a potential therapeutic strategy, but its effectiveness varies with tumor type and location.

Keywords:

VCAM1 astrocyte glioma glioma stem cell-like cells therapeutic target

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Published on: November 28, 2015

Area of Science:

Neuro-oncology
Tumor Microenvironment Research
Cancer Metastasis

Background:

Glioma progression and therapeutic resistance are driven by interactions between cancer cells and the tumor microenvironment (TME).
VCAM1 (Vascular Cell Adhesion Molecule 1) is implicated in metastasis in various cancers, but its role in the glioma TME is not well understood.

Purpose of the Study:

To investigate the function of VCAM1 in glioma.
To correlate VCAM1 expression with patient survival outcomes.
To assess the impact of astrocytic VCAM1 ablation on glioma growth and survival.

Main Methods:

Analysis of human glioma datasets for VCAM1 expression and survival correlation.
Characterization of VCAM1 expression in mouse glioma models (syngeneic and primary).
Selective ablation of VCAM1 in GLAST-positive astrocytes in glioma-bearing mice.

Main Results:

VCAM1 is highly expressed in proliferative glioma stem cell-like cells (GSLCs) and in TME-associated astrocytes.
Selective deletion of astrocytic VCAM1 significantly extended median survival in certain glioma models (e.g., GL261).
Survival benefits were dependent on tumor location and genetic background, with limited efficacy in aggressive tumors; clinical data showed VCAM1 correlates with survival in low-grade glioma but not glioblastoma.

Conclusions:

Astrocyte-derived VCAM1 is a key factor in glioma progression, facilitating tumor-TME interactions.
Targeting VCAM1 signaling is a potential microenvironment-focused therapeutic strategy for glioma.
Clinical application of VCAM1 targeting requires consideration of tumor heterogeneity (regional and genetic).