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Immunoconjugates in cervical cancer: a bibliometric and thematic mapping analysis of global research trends,

Xiaodong Wang1, Di Xiong2, Songli Cui1

  • 1Department of Oncology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, China.

Frontiers in Oncology
|May 11, 2026
PubMed
Abstract

Insights

Antibody drug conjugates are advancing cervical cancer treatment. Research shows a rapid evolution from foundational studies to clinical applications, focusing on safety, mechanisms, and new therapeutic strategies.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Immunoconjugates, especially antibody drug conjugates (ADCs), show promise for recurrent or metastatic cervical cancer.
  • A comprehensive quantitative analysis of the field's evolution over the past decade is lacking.

Purpose of the Study:

  • To quantitatively analyze the evolution of immunoconjugate research in cervical cancer over the last decade (2015-2024).
  • To identify key research themes, trends, and emerging hotspots in the field.

Main Methods:

  • Bibliometric analysis of 244 publications from Web of Science and Scopus (2015-2024).
  • Utilized bibliometrix in R for indicator calculation.
  • VOSviewer and CiteSpace were employed for keyword co-occurrence mapping and burst detection.

Main Results:

  • Publication output significantly increased post-2021, indicating a move towards clinical translation.
  • Identified five core research themes: safety/toxicity, hematologic malignancy influences, preclinical mechanisms, gynecologic oncology, and clinical trial design.
  • Burst analysis revealed a shift from early mechanistic terms to clinical hotspots like tissue factor and immunotherapy.

Conclusions:

  • Immunoconjugate research in cervical cancer has matured rapidly, transitioning from basic science to clinically relevant strategies.
  • The findings provide a roadmap for future translational research, emphasizing actionable targets, safety, and combination therapies.
Keywords:
antibody drug conjugatebibliometric analysiscervical cancerimmunoconjugatekeyword burst

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