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Related Experiment Video

Updated: May 12, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Left Bundle Branch Area Pacing vs. Biventricular Pacing for Cardiac Resynchronization: Propensity Score Analysis.

Fawzi Kerkouri1,2, Pierre Khattar3, Vincent Mansourati1

  • 1Department of Cardiology University Hospital of Brest Brest France.

Journal of Arrhythmia
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Left bundle branch area pacing (LBBAP) offers comparable cardiac resynchronization therapy outcomes to biventricular pacing (BIVP) but with fewer complications. This study shows LBBAP is a safe and effective alternative for CRT.

Keywords:
CRTarrythmiasconduction system pacingheart failureleft ventricular ejection fraction

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Left bundle branch area pacing (LBBAP) is an emerging alternative to biventricular pacing (BIVP) for cardiac resynchronization therapy (CRT).
  • Previous data suggest LBBAP may offer superior outcomes, but more evidence is needed.
  • This study compares LBBAP and BIVP for de novo CRT indications.

Purpose of the Study:

  • To compare procedural and clinical outcomes between LBBAP and BIVP in patients undergoing de novo cardiac resynchronization therapy.
  • To evaluate the safety and efficacy of LBBAP as an alternative to BIVP.
  • To assess long-term outcomes including heart failure hospitalizations and mortality.

Main Methods:

  • Retrospective study of 314 patients undergoing de novo CRT at two French centers (2022-2024).
  • Patients were divided into LBBAP (n=75) and BIVP (n=239) groups.
  • Inverse probability weighting propensity score (IPW-PS) was used to compare outcomes.

Main Results:

  • LBBAP was associated with shorter procedure times, narrower paced QRS, and fewer post-discharge complications compared to BIVP.
  • One-year improvements in left ventricular ejection fraction and hyper-response rates were similar between groups.
  • After IPW-PS, no significant differences were found in heart failure hospitalizations, arrhythmias, or mortality between LBBAP and BIVP.

Conclusions:

  • LBBAP demonstrates comparable resynchronization and clinical outcomes to BIVP for cardiac resynchronization therapy.
  • LBBAP is associated with a significant reduction in late device-related complications.
  • LBBAP represents a viable and potentially safer alternative to conventional BIVP.