A Case of Neoadjuvant Chemotherapy for Locally Advanced Inflammatory Breast Cancer With Low-Level ER Expression

Area of Science:

• Oncology
• Medical Case Study

Background:

• Inflammatory breast cancer (IBC) is a rare and aggressive form of breast carcinoma.
• IBC is characterized by dermal lymphatic invasion, presenting as skin edema and redness.

Purpose of the Study:

• To report a case of locally advanced inflammatory breast cancer (IBC) treated with neoadjuvant chemotherapy.
• To emphasize the role of multidisciplinary team (MDT) discussion in optimizing treatment and prognosis for IBC patients.

Main Methods:

• Diagnosis of locally advanced IBC.
• Neoadjuvant chemotherapy followed by modified radical mastectomy and split-thickness skin graft.
• Adjuvant radiotherapy, endocrine therapy, and capecitabine treatment based on MDT recommendations.

Main Results:

• The patient achieved a pathological complete response (pCR) after neoadjuvant chemotherapy.
• No signs of relapse or progression were observed during a 2-year follow-up period.
• Successful management through a coordinated, multidisciplinary approach.

Conclusions:

• Multidisciplinary team coordination is crucial for optimal treatment of locally advanced IBC.
• Effective management strategies can lead to favorable prognoses in IBC patients.
• This case demonstrates a successful treatment pathway for locally advanced IBC.