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Related Experiment Video

Updated: May 12, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Engineering Organ Conformality for Precise Intracellular Delivery.

Yanling Hu1,2, Dongliang Yang2, Zhen Yang3

  • 1College of Life and Health, Nanjing Polytechnic Institute, Nanjing, China.

Research (Washington, D.C.)
|May 11, 2026
PubMed
Summary

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Researchers developed POCKET, a flexible bioelectronic patch using kirigami for precise intracellular delivery on complex organs. This innovation improves drug delivery efficiency and therapeutic outcomes in organ treatment.

Area of Science:

  • Bioelectronic medicine
  • Biomaterials engineering
  • Cellular and molecular biology

Background:

  • Bioelectronic patches offer localized intracellular delivery but struggle with organ conformability and efficiency.
  • Anatomically complex organs present challenges for current bioelectronic patch technologies.

Purpose of the Study:

  • To introduce POCKET, a kirigami-based electrotransfection patch for conformable intracellular delivery on complex organ surfaces.
  • To establish a universal framework for maximizing organ coverage with bioelectronic patches.
  • To enhance spatial precision and therapeutic efficacy for organ treatments.

Main Methods:

  • Developed a kirigami-based bioelectronic patch (POCKET) for enhanced conformability.
  • Integrated mechanical design with interfacial bioelectronics for precise cell targeting.

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Last Updated: May 12, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
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Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Published on: October 24, 2014

  • Utilized electrotransfection to facilitate nanopore connection and transmembrane transport.

    • Main Results:

    • Achieved universal conformality for bioelectronic patches on complex organ surfaces.
    • Demonstrated enhanced electroporation and transmembrane transport for efficient drug delivery.
    • Improved spatial precision and therapeutic efficacy in complex organ environments.

    Conclusions:

    • POKET offers a conformable solution for intracellular delivery on complex organs.
    • The platform shows promise for advancing gene therapy, organ protection, and regenerative medicine.
    • This bioelectronic patch integrates mechanical conformability with interfacial bioelectronics for improved organ treatment.