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Engineering Organ Conformality for Precise Intracellular Delivery.

Yanling Hu^1,2, Dongliang Yang², Zhen Yang³

¹College of Life and Health, Nanjing Polytechnic Institute, Nanjing, China.

Research (Washington, D.C.)

|May 11, 2026

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Researchers developed POCKET, a flexible bioelectronic patch using kirigami for precise intracellular delivery on complex organs. This innovation improves drug delivery efficiency and therapeutic outcomes in organ treatment.

Area of Science:

Bioelectronic medicine
Biomaterials engineering
Cellular and molecular biology

Background:

Bioelectronic patches offer localized intracellular delivery but struggle with organ conformability and efficiency.
Anatomically complex organs present challenges for current bioelectronic patch technologies.

Purpose of the Study:

To introduce POCKET, a kirigami-based electrotransfection patch for conformable intracellular delivery on complex organ surfaces.
To establish a universal framework for maximizing organ coverage with bioelectronic patches.
To enhance spatial precision and therapeutic efficacy for organ treatments.

Main Methods:

Developed a kirigami-based bioelectronic patch (POCKET) for enhanced conformability.
Integrated mechanical design with interfacial bioelectronics for precise cell targeting.

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Last Updated: May 12, 2026

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Utilized electrotransfection to facilitate nanopore connection and transmembrane transport.

Main Results:

Achieved universal conformality for bioelectronic patches on complex organ surfaces.
Demonstrated enhanced electroporation and transmembrane transport for efficient drug delivery.
Improved spatial precision and therapeutic efficacy in complex organ environments.

Conclusions:

POKET offers a conformable solution for intracellular delivery on complex organs.
The platform shows promise for advancing gene therapy, organ protection, and regenerative medicine.
This bioelectronic patch integrates mechanical conformability with interfacial bioelectronics for improved organ treatment.