Related Experiment Video
Updated: May 12, 2026
08:40
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
Visible-Light-Curable Catechol-Reinforced Gelatin Bioglue for Rapid Hemostasis and Engineered Tissue Assembly
Ashfaq Ahmad1,2, Jian Shin1, Jaylord M Pioquinto3
1Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.
Biomaterials Research
|May 11, 2026
Summary
A new DOPA-tyrosine gelatin (DTG) bioglue offers strong adhesion to wet tissues. This bioinspired hydrogel adhesive shows promise for 3D bioprinting and surgical applications, improving tissue integration and hemostasis.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Adhesive Technology
Background:
- Hydrogel tissue adhesives are promising but struggle with wet surface adhesion.
- Mussel-inspired 3,4-dihydroxy-l-phenylalanine (DOPA) is key, but conventional methods limit clinical use.
Purpose of the Study:
- To develop a novel bioinspired hydrogel adhesive with enhanced adhesion and clinical potential.
- To create a versatile bioglue for tissue integration and 3D bioprinting.
Main Methods:
- Enzymatic conversion of tyrosine to DOPA in porcine gelatin.
- Formulation of a hybrid DOPA-tyrosine gelatin (DTG) bioglue.
- Visible-light-driven ruthenium-based crosslinking and characterization of shear-thinning properties.
Main Results:
- DTG bioglue demonstrated rapid curing and shear-thinning for 3D bioprinting.
- Successful tissue-tissue integration for large-area constructs was achieved.
- Superior hemostatic performance in rat liver and vascular injury models was observed.
Conclusions:
- DTG bioglue offers a promising next-generation adhesive biomaterial.
- The strategy addresses limitations in current adhesive technology for regenerative medicine and surgery.
