When protein losing enteropathy persists: A case series of viral and lymphatic-associated etiologies

Protein-losing enteropathy (PLE) is a rare condition that is characterized by loss of plasma protein in the intestines leading to hypoproteinemia with subsequent peripheral edema and possibly anasarca. The pathophysiology of PLE varies depending on the etiology and involves either intestinal mucosal injury or lymphatic system alterations. While transient PLE can occur in the setting of viral infections, persistent or recurrent PLE requires comprehensive evaluation and multidisciplinary management approach. Here, we present two cases of PLE: the first case secondary to a common pediatric infection and the second case of primary intestinal lymphangiectasia with severe symptoms improved with diet therapy.