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Glucose and Lipid Metabolic Mechanisms in Vascular Aging and Related Therapeutic Strategies

Fei Han1,2, Zuoshi Wen1, Chenxi Li1

  • 1Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, Zhejiang, China.

Reviews in Cardiovascular Medicine
|May 11, 2026
PubMed

Insights

Vascular aging, linked to metabolic issues like glucose and lipid disorders, increases vascular disease risk. Understanding this connection is key for early detection and treatment of aging blood vessels.

Area of Science:

  • Gerontology
  • Metabolic Medicine
  • Cardiovascular Research

Background:

  • Vascular aging is a significant risk factor for various vascular disorders.
  • Cellular and molecular mechanisms of vascular aging are closely linked to metabolic dysfunction, including glucose and lipid metabolism disturbances.
  • Understanding the interplay between metabolic disorders and vascular aging is critical for vascular disease prevention.

Purpose of the Study:

  • To review the metabolic mechanisms underlying vascular aging.
  • To highlight clinical biomarkers and assessment strategies for vascular senescence.
  • To summarize therapeutic approaches for improving metabolic function in vascular aging.

Main Methods:

  • Literature review focusing on metabolic mechanisms of vascular aging.
  • Analysis of clinical biomarkers and assessment tools for vascular senescence.
  • Synthesis of current therapeutic strategies targeting metabolic dysfunction.

Main Results:

  • Vascular aging is intricately tied to disruptions in glucose and lipid metabolism.
  • Specific clinical biomarkers and assessment strategies can aid in early recognition.
  • Therapeutic interventions aimed at metabolic function show promise.

Conclusions:

  • Metabolic dysfunction is a core driver of vascular aging.
  • Early clinical identification and targeted interventions are essential for managing vascular senescence.
  • Improving metabolic health is a key strategy for mitigating vascular aging and preventing disease.
Keywords:
glucoselipid metabolismmulti-omicsvascular aging

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