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Published on: July 9, 2014
Analysis of Cytomegalovirus Infection Affecting the Stomach
Yang Diao1,2,3,4, Ye Zong1,2,3,4, Rui Xu5
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Gastroenterology Research and Practice
|May 11, 2026
Summary
Cytomegalovirus (CMV) gastritis, increasingly common in immunocompromised individuals, presents with gastrointestinal symptoms. Early diagnosis via endoscopic biopsy and antiviral treatment are key for recovery, though complications like gastric cancer can occur.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Oncology
Background:
- The incidence of cytomegalovirus (CMV) infection is rising globally.
- CMV infection can affect the stomach, leading to CMV gastritis.
Purpose of the Study:
- To explore the clinical characteristics, diagnosis, treatments, and prognosis of gastric lesions caused by CMV infection.
- To provide insights into managing CMV gastritis.
Main Methods:
- A systematic review of English literature on CMV infection involving the stomach.
- Analysis of 39 publications reporting 44 cases of CMV gastritis.
Main Results:
- Common symptoms include abdominal pain, nausea, vomiting, and gastrointestinal bleeding.
- Endoscopic findings frequently showed ulcers, erosions, and erythema.
- Most patients had a history of immunosuppression; diagnosis confirmed by biopsy and CMV DNA testing.
- Antiviral therapy led to improvement in most cases, with some spontaneous resolution.
- A small percentage progressed to gastric cancer or experienced fatal outcomes.
Conclusions:
- CMV gastritis should be considered in immunocompromised patients with gastrointestinal symptoms.
- Endoscopic biopsy with histopathological examination is crucial for diagnosis.
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