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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Related Experiment Videos

lncRNA EGOT across cancers: TCGA analysis.

Tomasz Kolenda1, Joanna Kozłowska-Masłoń1,2,3, Kacper Guglas1,4

  • 1Greater Poland Cancer Center, Research and Implementation Unit, Poznan, Poland.

Archives of Medical Science : AMS
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

The eosinophil granule ontogeny transcript (EGOT) long non-coding RNA shows varied prognostic value across cancers. EGOT may serve as a biomarker, potentially linked to viral activity and immune response in tumorigenesis.

Keywords:
TCGAbiomarkerlncRNAnon-coding RNAoncogenesuppressorviruses-depending oncogenesis

Related Experiment Videos

Area of Science:

  • * Molecular oncology
  • * Epigenetics
  • * Cancer biomarkers

Background:

  • * Long non-coding RNAs (lncRNAs) regulate cellular phenotypes epigenetically.
  • * Eosinophil granule ontogeny transcript (EGOT) expression correlates with tumorigenesis and viral infections.
  • * The precise biological role and diagnostic potential of EGOT remain under investigation.

Purpose of the Study:

  • * To analyze the role of EGOT in various cancers.
  • * To investigate the association between EGOT expression and patient survival.
  • * To explore EGOT's relationship with cellular pathways, immune profiles, and tumor characteristics.

Main Methods:

  • * Analysis of EGOT expression data from The Cancer Genome Atlas (TCGA).
  • * Examination of pathological and clinical features associated with EGOT levels.
  • * Assessment of cellular pathways, genomic alterations, and immune profiles linked to EGOT.

Main Results:

  • * Higher EGOT expression correlated with better survival in breast invasive carcinoma (BRCA), head and neck squamous cell carcinoma (HNSC), and kidney renal clear cell carcinoma (KIRC).
  • * Worse patient survival was associated with higher EGOT expression in liver hepatocellular carcinoma (LIHC).
  • * Significant variations in EGOT expression, cellular pathways, immune profiles, proliferation, and tumor heterogeneity were observed across different cancer types, particularly in BRCA and KIRC.

Conclusions:

  • * EGOT demonstrates potential as a prognostic biomarker in clinical oncology.
  • * Viral activity and immunological response to viral infection may link cancer types and EGOT expression changes.
  • * Further research is warranted to elucidate EGOT's full clinical utility.