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lncRNA EGOT across cancers: TCGA analysis
Tomasz Kolenda1, Joanna Kozłowska-Masłoń1,2,3, Kacper Guglas1,4
1Greater Poland Cancer Center, Research and Implementation Unit, Poznan, Poland.
Archives of Medical Science : AMS
|May 11, 2026
Summary
The eosinophil granule ontogeny transcript (EGOT) long non-coding RNA shows varied prognostic value across cancers. EGOT may serve as a biomarker, potentially linked to viral activity and immune response in tumorigenesis.
Area of Science:
- * Molecular oncology
- * Epigenetics
- * Cancer biomarkers
Background:
- * Long non-coding RNAs (lncRNAs) regulate cellular phenotypes epigenetically.
- * Eosinophil granule ontogeny transcript (EGOT) expression correlates with tumorigenesis and viral infections.
- * The precise biological role and diagnostic potential of EGOT remain under investigation.
Purpose of the Study:
- * To analyze the role of EGOT in various cancers.
- * To investigate the association between EGOT expression and patient survival.
- * To explore EGOT's relationship with cellular pathways, immune profiles, and tumor characteristics.
Main Methods:
- * Analysis of EGOT expression data from The Cancer Genome Atlas (TCGA).
- * Examination of pathological and clinical features associated with EGOT levels.
- * Assessment of cellular pathways, genomic alterations, and immune profiles linked to EGOT.
Main Results:
- * Higher EGOT expression correlated with better survival in breast invasive carcinoma (BRCA), head and neck squamous cell carcinoma (HNSC), and kidney renal clear cell carcinoma (KIRC).
- * Worse patient survival was associated with higher EGOT expression in liver hepatocellular carcinoma (LIHC).
- * Significant variations in EGOT expression, cellular pathways, immune profiles, proliferation, and tumor heterogeneity were observed across different cancer types, particularly in BRCA and KIRC.
Conclusions:
- * EGOT demonstrates potential as a prognostic biomarker in clinical oncology.
- * Viral activity and immunological response to viral infection may link cancer types and EGOT expression changes.
- * Further research is warranted to elucidate EGOT's full clinical utility.
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