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Comprehensive analysis of the lncRNA-miRNA-mRNA ceRNA network in aortic dissection.

Fengwen Xie¹, Jichun Liu¹

¹Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Archives of Medical Science : AMS

|May 11, 2026

Summary

This study identifies differentially expressed long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in aortic dissection (AD). A competing endogenous RNA (ceRNA) network was constructed to offer new insights into AD diagnosis and treatment.

Related Concept Videos

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Area of Science:

Cardiovascular Biology
Molecular Biology
Genomics

Background:

Aortic dissection (AD) is a life-threatening cardiovascular disease.
Long noncoding RNAs (lncRNAs) play roles in disease by acting as competing endogenous RNAs (ceRNAs) that regulate microRNA (miRNA) and messenger RNA (mRNA) levels.

Purpose of the Study:

To construct and analyze the lncRNA-miRNA-mRNA ceRNA network in aortic dissection.
To identify potential diagnostic markers and therapeutic targets for AD.

Main Methods:

Downloaded and analyzed Gene Expression Omnibus (GEO) data (GSE52093) for AD and normal samples.
Identified differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs).
Constructed the ceRNA network using bioinformatics databases (miRcode, miRDB, miRTarBase, TargetScan) and visualized it with Cytoscape.

Keywords:

Gene Expression Omnibus aortic dissection competitive endogenous RNA long noncoding RNA

Related Experiment Videos

Main Results:

Identified 13 differentially expressed lncRNAs and 472 differentially expressed mRNAs in AD samples.
Constructed a ceRNA network involving 7 lncRNAs, 18 miRNAs, and 48 mRNAs.

Conclusions:

A lncRNA-miRNA-mRNA ceRNA network in AD was successfully constructed using bioinformatics approaches.
This network may offer novel perspectives for AD diagnosis and the development of potential therapeutic strategies.