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Complete Blood-Count-Derived Inflammatory Markers Across Acute Mood Episodes
1Department of Psychiatry, Ondokuz Mayıs University, 55270 Samsun, Turkey.
Alpha Psychiatry
|May 11, 2026
Summary
Systemic inflammation markers, including neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), are elevated in bipolar disorder (BD) and major depressive disorder (MDD) patients. Antidepressant use showed an inverse association with PLR and MLR.
Area of Science:
- Hematology
- Psychiatry
- Immunology
Background:
- Systemic inflammation is increasingly implicated in mood disorders.
- Previous studies on inflammation markers in mood disorders yielded inconsistent results.
Purpose of the Study:
- To compare complete blood count (CBC)-derived inflammatory indices in patients with bipolar disorder (BD) and major depressive disorder (MDD).
- To investigate the influence of psychotropic medications on these inflammatory markers.
Main Methods:
- Retrospective chart review of inpatients with BD or MDD and a healthy control group.
- Calculation of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) from initial CBC.
- Statistical analysis using Kruskal-Wallis, Mann-Whitney U tests, ANCOVA, and regression models to control for confounders.
Main Results:
- NLR and MLR were higher in mood disorder groups compared to healthy controls.
- PLR elevation was specific to the MDD group; SII was elevated in depressive episodes but not mania.
- Antidepressant use was negatively associated with PLR and MLR values after adjusting for covariates.
Conclusions:
- Acute mood episodes are associated with increased inflammation-related hematologic markers.
- The inverse association between antidepressant use and specific inflammatory markers suggests a link between medication and systemic inflammation in hospitalized patients.
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