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Updated: May 12, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Clinical Applications of Artificial Intelligence in Structural Heart Disease
Haytham Allaham1, Diljon Chahal1, Mukta Srivastava1
1Division of Cardiovascular Medicine, University of Maryland Medical Center, Baltimore, Maryland.
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Transcatheter cardiac interventions have advanced substantially over the past decade, providing less invasive therapeutic options for an expanding spectrum of structural heart disease. As procedural complexity increases, artificial intelligence (AI) has emerged as a complementary tool to support clinical decision making. Early studies demonstrated that AI can automate imaging analysis, quantify cardiac anatomy, and assess hemodynamics with greater accuracy, efficiency, and reproducibility than conventional methods. This comprehensive review summarizes current clinical applications of AI in structural heart disease, focusing on its role in diagnosis, assessment of disease progression, risk stratification, procedural planning, and prediction of clinical outcomes.
