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Updated: May 12, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Osteoradionecrosis After Modern Radiotherapy for Oral Cavity Cancer: Incidence and Risk Factors.

Alyssa Farley¹, Taylor Petery¹, Nigel Dick¹

¹Department of Radiation Oncology University of Cincinnati Cincinnati Ohio USA.

Laryngoscope Investigative Otolaryngology

|May 11, 2026

Summary

Osteoradionecrosis (ORN) risk is higher in oral cavity cancer patients than previously thought. Surgery involving jawbone removal significantly increases ORN development after radiation therapy.

Keywords:

oral cavity cancer osteoradionecrosis rates radiation therapy

Related Experiment Videos

Last Updated: May 12, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Area of Science:

Oncology
Radiation Oncology
Oral Surgery

Background:

Osteoradionecrosis (ORN) is a serious complication following head and neck cancer (HNC) radiation therapy, with reported incidences varying widely.
Establishing contemporary ORN rates is crucial for accurate patient counseling and treatment planning.

Purpose of the Study:

To determine the current incidence of ORN in patients treated exclusively with intensity-modulated radiation therapy (IMRT) for oral cavity squamous cell carcinoma (OCSCC).
To identify risk factors associated with ORN development in this specific patient population.

Main Methods:

Retrospective chart review of 172 OCSCC patients treated between 2013 and 2022.
Data collection included patient demographics, cancer stage, surgical procedures (mandibulectomy/maxillectomy), and radiation/chemotherapy details.
ORN was defined by clinical and radiographic evidence of bone exposure.

Main Results:

The 3-year incidence of ORN in the OCSCC cohort was 24%.
Patients undergoing mandibulectomy or maxillectomy prior to radiation had a significantly higher risk of developing ORN (28.4% vs. 18.1%).
The hazard ratio for ORN development following jawbone surgery was 1.93.

Conclusions:

The incidence of ORN in OCSCC patients treated with IMRT appears higher than in broader HNC cohorts.
Surgical resection of the mandible or maxilla is a significant risk factor for ORN development in OCSCC patients.