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Changes in serum cardiac troponin I after seizures: A marker for persistent subtle left ventricular myocardial

Mona Hafez1, Shaimaa Rakha1, Khaled Fathy2

  • 1Pediatric Cardiology Unit, Department of Pediatrics, Mansoura University, Faculty of Medicine, Mansoura, Egypt.

Annals of Pediatric Cardiology
|May 11, 2026
PubMed

Insights

Pediatric epilepsy is linked to cardiac issues. This study found that elevated serum cardiac troponin I (cTnI) after seizures in children indicates subtle left ventricular myocardial dysfunction, even when levels normalize.

Area of Science:

  • Cardiology
  • Neurology
  • Pediatrics

Background:

  • Epilepsy is a common childhood neurological disorder.
  • Cardiovascular comorbidities are frequently associated with epilepsy.
  • Assessing left ventricular (LV) myocardial dysfunction in epileptic children is crucial.

Purpose of the Study:

  • To evaluate left ventricular (LV) myocardial dysfunction in children with epilepsy.
  • To utilize serum cardiac troponin I (cTnI) and advanced echocardiographic techniques.
  • To investigate the relationship between cTnI levels and cardiac function.

Main Methods:

  • Prospective case-control study with 55 children with epilepsy and 40 controls.
  • Serum cTnI measured 12-24 hours post-seizure and at 4 weeks.
  • Echocardiography including Tissue Doppler Imaging (TDI) and 2D Speckle Tracking (2D-STE) performed for elevated cTnI.

Main Results:

  • Elevated cTnI observed in 27.5% of children with epilepsy.
  • TDI and 2D-STE revealed significant LV myocardial dysfunction (impaired strain and velocities).
  • Post-seizure cTnI levels correlated negatively with myocardial function parameters.

Conclusions:

  • Post-seizure serum cTnI is a marker for persistent LV myocardial changes in epileptic children.
  • TDI and 2D-STE parameters highlight subtle myocardial dysfunction.
  • Normalization of cTnI suggests myocardial stunning, potentially leading to injury; seizure control and cardiac surveillance are vital.
Abstract

Keywords:
Epilepsyleft ventriclemyocardial dysfunctiontroponin I

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