Effect of Polyethylene Glycol Loxenatide Treatment on Body Weight in Patients With Type 2 Diabetes With Different
Peng Xu1,2, Chen Dong3, Xingzhi Xu3
1The Second Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, hust.edu.cn.
Introduction:
Real-world data on the effect of polyethylene glycol loxenatide (PEG-Loxe) in patients with Type 2 diabetes mellitus (T2DM) with normal body mass index (BMI) are lacking. Therefore, this study aims to observe the effect of PEG-Loxe on the weight of patients with T2DM with different BMIs.
Methods:
This single-center, retrospective real-world study included patients with T2DM, aged ≥ 18 years, and receiving PEG-Loxe/sodium-glucose cotransporter 2 inhibitor (SGLT2i). The primary endpoint was change in body weight after 24 weeks of treatment. Secondary endpoints included proportion of patients with body weight reduction < 5.0% and < 10%, changes in BMI, and glycosylated hemoglobin (HbA1c).
Results:
Overall, 487 patients treated with SGLT2i or PEG-Loxe were identified; after propensity score matching, 68 patients were included in each group. After 24 weeks, the mean change in body weight and BMI was -1.2 (-2.3, -0.1) and -0.4 (-0.8, -0.1) in the PEG-Loxe group and -2.4 (-3.5, -1.3) and -0.7 (-1.1, -0.4) in the SGLT2i group. A ≥ 5% and ≥ 10% weight loss was noted by 32.4% and 8.8% of patients in the PEG-Loxe group, with a mean change in HbA1c (%) of -1.48 (-1.98, -0.99). Weight loss (≥ 5%) in obese patients (BMI > 28 kg/m2) was greater (PEG-Loxe: 53.3%, SGLT2i: 57.1%) compared to patients with 24 ≤ BMI < 28 kg/m2 (PEG-Loxe: 25.7%, SGLT2i: 41.4%) and BMI < 24 kg/m2 (PEG-Loxe: 27.8%, SGLT2i: 28%).
Conclusion:
PEG-Loxe resulted in weight loss and glycemic control in patients with T2DM. The weight loss was negatively correlated with baseline BMI without excessive weight loss in normal BMI, supporting PEG-Loxe's use in this group. Trial Registration: Chinese Registry of Clinical Trials: ChiCTR2400087532.
Related Concept Videos
Drug Dosing: Obese Patients
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
