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Updated: May 12, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
What should neurologists expect to observe in relapsing polychondritis and VEXAS?
Mickael Bonnan1, Quang Tuan Rémy Nguyen1, Etienne Crickx2,3
1Neurology Department, Henri Mondor Hospital, Créteil, France.
Abstract:
Relapsing polychondritis (RP) and VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) are two clinically overlapping conditions in which neurological complications remain uncommon. Based on the existing literature, neurological involvement in RP most frequently comprises meningitis, encephalitis, cranial nerve palsies, and stroke, whereas VEXAS is additionally characterized by peripheral nerve and muscle involvement. This scoping review summarizes the neurological manifestations associated with RP and VEXAS and highlights the current gaps in knowledge regarding these complications.
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