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Development of an excel-based decision support tool for graves orbitopathy.

Deniz Kilic¹, Mustafa Aksoy¹

¹Department of Ophthalmology, Worldeye Hospital, Izmir, Türkiye.

Orbit (Amsterdam, Netherlands)

|May 11, 2026

Summary

A new Excel tool operationalizes European Group on Graves

Area of Science:

Ophthalmology
Endocrinology
Clinical Decision Support Systems

Background:

Graves' orbitopathy (GO) management requires adherence to complex guidelines.
Operationalizing the 2021 European Group on Graves' Orbitopathy (EUGOGO) recommendations in clinical practice presents challenges.
Standardizing GO care is crucial for consistent patient outcomes.

Purpose of the Study:

To develop and assess the technical feasibility of a rule-based Excel decision support tool.
To operationalize the 2021 EUGOGO recommendations for Graves' orbitopathy (GO).
To facilitate the integration of GO management guidelines into routine clinical practice.

Main Methods:

A rule-based Excel tool was developed integrating EUGOGO inputs (CAS, severity, GO-QoL).

Keywords:

EUGOGO Graves’ orbitopathy decision support

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Progression parameters served as override criteria for disease activity classification.

Proof-of-concept validation used clinical case scenarios against expert decisions.

Main Results:

The tool produced structured summaries of disease activity, severity, and management options.
Automated outputs were generated from routinely collected clinical parameters.
Pilot use confirmed technical feasibility and internal consistency of rule execution.

Conclusions:

A pragmatic, rule-based Excel tool can operationalize EUGOGO recommendations for GO.
The tool supports documentation and workflow in GO management.
Further validation and prospective evaluation are necessary.