Home-based exercise training in boys with Duchenne muscular dystrophy: A 12-month intervention study

Area of Science:

• Neuromuscular Disorders
• Pediatric Rehabilitation
• Exercise Science

Background:

• Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder impacting physical activity and ambulation.
• Promoting physical activity is crucial for children with disabilities, as recommended by the WHO.
• Limited research exists on the long-term effects of home-based exercise programs for boys with DMD.

Purpose of the Study:

• To assess changes in physical activity (PA), physical function, and quality of life (QoL) after a one-year home-based exercise program in boys with DMD.
• To evaluate the suitability and safety of this exercise intervention for boys with DMD.
• To compare outcomes between an intervention group and a non-intervention control group.

Main Methods:

• Prospective longitudinal intervention study involving 12 boys with DMD in an exercise group and 11 in a control group.
• Individually tailored home-based program with strength and endurance training, three times weekly for one year.
• Physical activity monitored via accelerometry; secondary outcomes included upper-limb function, lung function, grip strength, endurance, and QoL.

Main Results:

• The intervention group showed increased light and moderate-to-vigorous PA levels, while the control group showed a decline.
• Sedentary time increased in both groups; no adverse events were reported from the exercise program.
• Upper-limb function declined in the intervention group, but other measures remained stable with a slight QoL improvement.

Conclusions:

• Home-based, moderate-intensity exercise is beneficial and safe for boys with DMD.
• This exercise approach may help sustain PA levels, functional abilities, and QoL in this population.
• Further research should explore long-term adherence and broader functional outcomes.