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Updated: May 12, 2026
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
T cells, the Next Big Target in Axial Spondyloarthritis?
Mansi K Aparnathi1, Nigil Haroon1,2
1Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.
Arthritis & Rheumatology (Hoboken, N.J.)
|May 11, 2026
Summary
Axial spondyloarthritis (axSpA) involves diverse T cell subsets driving inflammation. Targeting these T cells, including Th17 and TRM cells, offers new therapeutic avenues for axSpA.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with significant immune system involvement.
- T cells are recognized as key players in the complex immune dysregulation underlying axSpA pathogenesis.
Purpose of the Study:
- To review current knowledge on T cell subsets in axSpA.
- To elucidate their pathogenic mechanisms and explore emerging therapeutic strategies targeting T cells.
Main Methods:
- Synthesis of current research on T cell subsets in axSpA.
- Analysis of pathogenic mechanisms involving conventional and innate-like T cells.
- Review of therapeutic strategies including direct and indirect targeting.
Main Results:
- Conventional T cells (CD8+, CD4+ Th17, Treg, TRM) and innate-like T cells (γδ, MAIT, iNKT) contribute to axSpA.
- IL-17 production driven by IL-23 plays a significant role in inflammation and tissue damage.
- Cytokine milieu complexity may explain inefficacy of some inhibitors.
Conclusions:
- The intricate interplay of T cell subsets in axSpA pathogenesis necessitates targeted treatments.
- Emerging therapies include anti-TRBV9 antibody therapy, JAK inhibition, and targeting IL-17 and TNF.
- Further research can lead to personalized and combination therapies for axSpA.
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