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Updated: May 12, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

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Published on: September 28, 2022

Epstein-Barr virus receptors: classification, functional mechanisms, and pathogenic implications.

Hezirui Gu^1,2,3, Shuran Yang^1,2,3, Liting Song^1,2,3

¹Hunan Key Laboratory of Cancer Metabolism Changsha, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Journal of Virology

|May 11, 2026

Summary

Epstein-Barr virus (EBV) infection involves specific host cell receptors like CD21 and DSC2. Targeting these EBV receptors offers potential for new antiviral therapies and cancer treatments.

Keywords:

CD21 DSC2 EBV receptors EphA2 Epstein-Barr virus R9AP

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Published on: May 27, 2011

Area of Science:

Virology
Cell Biology
Immunology

Background:

Epstein-Barr virus (EBV), a prevalent γ-herpesvirus, infects B cells and epithelial cells.
EBV is linked to lymphomas and epithelial cancers, posing health risks.
Current treatments for EBV are limited, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

To review and classify known Epstein-Barr virus (EBV) receptors.
To analyze the structural characteristics and molecular mechanisms of EBV receptors.
To explore the potential of targeting EBV receptors for therapeutic interventions.

Main Methods:

Literature review of identified EBV receptors.
Comparative analysis of receptor function in B cells versus epithelial cells.
Discussion of current research limitations and future directions.

Main Results:

Identified EBV receptors include CD21, NRP1, EphA2, R9AP, and DSC2.
EBV receptors exhibit differential functional pathways in B cells and epithelial cells.
Targeting EBV receptors shows promise for antiviral therapy, vaccine development, and cancer immunotherapy.

Conclusions:

Understanding EBV receptor mechanisms is crucial for developing effective treatments.
Targeting EBV receptors presents a promising avenue for preventing and treating EBV-associated diseases.
Further research is needed to fully elucidate EBV receptor functions and therapeutic potential.