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Updated: May 12, 2026
Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications
Published on: October 5, 2018
Detection of anatomical changes induced by gold nanoparticle-mediated selective photothermolysis in acne using
Natacha Quezada1,2, Ximena Wortsman3,4,5
1Department of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, Avenida Libertador Bernardo O'Higgins 340, 8331150, Santiago, Chile.
Abstract:
Acne is the most common dermatologic disease, and to date, acne treatments have not been monitored using imaging. This study evaluates the anatomical changes induced by a new acne treatment, selective photothermolysis, using gold nanoparticles, both clinically and with ultra-high-frequency ultrasound. Three adolescent patients with mild acne underwent a three-session treatment protocol combining nano-gold application with Q-Switched 1064 nm laser therapy. We found visible improvements in pore size and evidence of targeted thermal impact on sebaceous structures and neighboring tissues. These findings support the use of ultrasound as a valuable non-invasive tool for monitoring treatment effectiveness.
