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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Updated: May 12, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.

Jade L Taylor1, Eric A Pereira da Silva1, Hannah M Voorhees1

  • 1Department of Pharmacology, University of California, Davis, CA, USA.

Handbook of Experimental Pharmacology
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Metabolic syndrome (MetS) involves interconnected risk factors increasing cardiovascular disease (CVD) risk. This chapter reviews animal models for studying MetS-cardiovascular complications, aiding research translation to human health.

Keywords:
DiabetesGLP-1HFpEFHypertensionMyogenic toneObesitySGLT2db/db

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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

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Area of Science:

  • Cardiovascular Research
  • Metabolic Disorders
  • Animal Models in Medicine

Background:

  • Metabolic syndrome (MetS) is a cluster of conditions including obesity, insulin resistance, hypertension, and dyslipidemia.
  • These factors significantly elevate the risk of developing cardiovascular diseases (CVDs).
  • Understanding MetS-associated cardiovascular complications is crucial for effective disease management.

Purpose of the Study:

  • To provide a comprehensive overview of animal models used in MetS cardiovascular research.
  • To analyze the strengths and limitations of various animal models.
  • To explore the translation of findings from animal models to human cardiovascular complications.

Main Methods:

  • Review of commonly used animal models: monogenic/polygenic rodents, diet-induced, chemically induced, and large-animal systems.
  • Analysis of cardiac and vascular alterations observed in MetS.
  • Integration of experimental model findings with human clinical data.

Main Results:

  • Diverse animal models offer valuable insights into MetS pathophysiology and cardiovascular effects.
  • Each model presents unique advantages and disadvantages for studying specific aspects of MetS.
  • Observed cardiac and vascular changes in models show parallels with human conditions.

Conclusions:

  • Animal models are essential tools for investigating MetS-related cardiovascular complications.
  • Comparative analysis of models aids in selecting appropriate systems for specific research questions.
  • Bridging animal research with human data is key to advancing therapeutic strategies for MetS-induced CVDs.