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Related Concept Videos

Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Related Experiment Video

Updated: May 12, 2026

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
08:33

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

Mechanisms driving thoracic aortic aneurysm instability.

Erica L Schwarz1, David S Li2,3, Colin W Means2

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT, USA. erica.schwarz@yale.edu.

Biomechanics and Modeling in Mechanobiology
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Computational models simulate thoracic aortic aneurysm progression, revealing that size and expansion rate alone don't predict outcomes. This approach improves patient-specific risk prediction for thoracic aortic aneurysms.

Keywords:
Finite element modelingMechanobiological stabilityThoracic aortic aneurysm

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Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
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Last Updated: May 12, 2026

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
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Published on: August 24, 2019

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
09:32

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Published on: September 19, 2018

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Cardiovascular Research

Background:

  • Thoracic aortic aneurysms (TAAs) involve complex biological and mechanical factors.
  • Current risk stratification for TAAs relies on size and expansion rate, which are insufficient predictors of clinical outcomes like dissection or rupture.

Purpose of the Study:

  • To develop and validate a computational biomechanical model for simulating TAA progression.
  • To investigate the influence of rate-dependent parameters on TAA natural history and clinical phenotypes.

Main Methods:

  • Utilized a constrained mixture theory of growth and remodeling to simulate lesion progression in TAAs.
  • Incorporated insults to vascular wall material properties and cellular sensitivity to mechanical environments.
  • Covaried rate-dependent parameters influencing aneurysm growth dynamics.

Main Results:

  • The model successfully simulated clinically relevant TAA phenotypes, including divergent progression pathways from similar initial conditions.
  • Demonstrated that the model can capture variations in aneurysm behavior not predicted by size or expansion rate alone.
  • Highlighted the importance of considering material properties and cellular responses in TAA development.

Conclusions:

  • The developed computational framework provides a foundation for more accurate, patient-specific risk prediction in TAAs.
  • This approach can integrate machine learning tools for accelerated clinical translation in TAA management.
  • Offers deeper insights into the mechanisms governing TAA behavior beyond traditional metrics.