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ASO Visual Abstract: Association Between Clinical Tumor Stage and Response to Total Neoadjuvant Therapy in Rectal

Emily F Simon1, Kamil Erozkan2, Kristen M Westfall2

  • 1Division of Colorectal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. emily.simon2@uhhospitals.org.

Annals of Surgical Oncology
|May 11, 2026
PubMed
Abstract

No abstract available in PubMed .

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...