Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.

Journal of affective disorders·2026

Same author

Disparities in Activation and Use of Patient Portals Among Spanish-Speaking Patients.

Applied clinical informatics·2026

Same author

How to Educate Learners to Manipulate Equipment in Trauma (HELMET): An Educational Workshop on Football Equipment Removal in Trauma Care.

Cureus·2026

Same author

Dose-dependent white matter changes associated with repetitive head impacts in former American football players.

Brain communications·2026

Same author

Validity of the NINDS traumatic encephalopathy syndrome criteria for predicting chronic traumatic encephalopathy.

medRxiv : the preprint server for health sciences·2026

Same author

A new type of table one: showing instead of telling.

Journal of clinical epidemiology·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury

Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury

Published on: February 21, 2025

Brain Cancer Mortality following Traumatic Brain Injury: A TBI Model Systems Study.

Charlotte B Luster¹, Shanti M Pinto^1,2, Mitra D McLarney^1,3,4

¹Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA.

Neuroepidemiology

|May 11, 2026

Summary

This summary is machine-generated.

Individuals with traumatic brain injury (TBI) have a 1.75-fold higher risk of brain cancer death. Gunshot wound-related TBI and mild TBI showed significantly increased mortality, suggesting potential targets for prevention.

Keywords:

Brain cancer Mortality studies Neuroepidemiology Rehabilitation Traumatic brain injury

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Related Experiment Videos

Last Updated: May 13, 2026

Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury

Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury

Published on: February 21, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Area of Science:

Neuroscience
Oncology
Epidemiology

Background:

Traumatic brain injury (TBI) is increasingly recognized as a potential risk factor for developing brain cancer.
Understanding the relationship between TBI and subsequent brain cancer is crucial for public health.
Existing evidence necessitates a direct comparison of brain cancer mortality rates in TBI survivors versus the general population.

Purpose of the Study:

To compare brain cancer mortality rates in individuals with a history of TBI against the general population.
To identify specific TBI characteristics associated with elevated brain cancer risk.
To provide data that may inform early prevention strategies for TBI-related brain cancers.

Main Methods:

A retrospective cohort study utilizing the TBI Model Systems (TBIMS) National Database (1987-2024).
Inclusion criteria: 20,211 individuals admitted for inpatient rehabilitation post-acute TBI hospitalization.
Brain cancer mortality was determined from death certificates; standardized mortality ratios (SMRs) were calculated against a matched general population using NIOSH LTASR R package.

Main Results:

A total of 4,297 decedents were analyzed, with 18 confirmed brain cancer deaths.
The overall brain cancer mortality rate in the TBI cohort was significantly higher than the general population (SMR=1.75; 95% CI: 1.04-2.77).
Elevated mortality was particularly noted in TBI survivors with gunshot wound (GSW)-related TBI (SMR=14.29) and mild TBI (mTBI) (SMR=3.88), but not moderate-to-severe TBI.

Conclusions:

Individuals with TBI exhibit a 75% increased likelihood of dying from brain cancer compared to the general population.
Gunshot wound-related TBI and mild TBI are associated with a significantly higher risk of brain cancer mortality.
These findings highlight the need for further research into the causal mechanisms and potential for targeted early prevention of brain cancer following TBI.