Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 13, 2026

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

Method for Selective REM Sleep Deprivation using The Selective Nose Flicking for Forgetting REM (SNiFFer).

Kazuki Nagai1, Iyo Koyanagi2, Chinatsu Kawakami3

  • 1Department of Humanics, University of Tsukuba; International Institute for Integrative Sleep Medicine, Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba; Division of Neurophysiology, Department of Physiology and Cell biology, Kobe University School of Medicine.

Journal of Visualized Experiments : Jove
|May 11, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of cardiac and pulmonary pressure for transatrial-to-left-ventricular cannulation: implications for surgical safety.

Journal of thoracic disease·2026
Same author

Real-Time Prediction Method of Shale Gas Fracturing Construction Pressure Based on MS-1DCNN-TFT Neural Network.

ACS omega·2026
Same author

Social isolation and loneliness associate with early menopause and mortality in women: a UK Biobank cohort study.

BMC medicine·2026
Same author

A Hidden Minor Papilla Carcinoma Unveiled by a Santorinicele in Complete Pancreas Divisum.

Gastrointestinal endoscopy·2026
Same author

A decade of clinical course and prognostic determinants in type 1 autoimmune pancreatitis: insights from a 10-year longitudinal multicenter retrospective study.

Journal of gastroenterology·2026
Same author

Transatrial left-ventricular cannulation for a shaggy aorta in aortic arch surgery: a case report.

General thoracic and cardiovascular surgery cases·2026

Researchers developed SNiFFer, a gentle method using nasal stimulation to selectively deprive rodents of Rapid Eye Movement (REM) sleep. This technique aids memory consolidation studies by minimizing stress and improving experimental control.

Area of Science:

  • Neuroscience
  • Sleep Science
  • Behavioral Neuroscience

Background:

  • Sleep is vital, with distinct Rapid Eye Movement (REM) and non-REM stages.
  • Existing REM sleep deprivation methods often cause stress and habituation, complicating research.
  • Understanding REM sleep's function requires precise and minimally invasive deprivation techniques.

Purpose of the Study:

  • To introduce SNiFFer, a novel, gentle, and selective method for REM sleep deprivation in rodents.
  • To validate the efficacy and specificity of SNiFFer in disrupting REM sleep.
  • To investigate the role of REM sleep in memory consolidation using the SNiFFer technique.

Main Methods:

  • Developed SNiFFer: a tactile method using gentle nasal stimulation (paintbrush) during REM sleep.

More Related Videos

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

Related Experiment Videos

Last Updated: May 13, 2026

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

  • Employed AI-based real-time Electroencephalography (EEG) for precise sleep-stage classification and intervention timing.
  • Utilized a yoked control group receiving stimulation regardless of sleep state for comparison.

    • Main Results:

    • SNiFFer effectively reduced total REM sleep episode duration and frequency.
    • The AI-EEG system ensured selective REM sleep deprivation.
    • Animals subjected to REM sleep deprivation showed impaired memory consolidation in a Trace Fear Conditioning paradigm.

    Conclusions:

    • SNiFFer provides a highly selective and minimally invasive approach for REM sleep deprivation in mice.
    • The technique allows for precise experimental control, facilitating research on REM sleep functions.
    • SNiFFer opens new avenues for studying REM sleep's impact on memory and cognition.