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Risk Factors for the Progression of Pyogenic Liver Abscess to Sepsis and Development of a Predictive Model.
Xianzhi Cheng1, Jingxin Wang1, Hong Zhang2
1Department of Pharmacy, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
The American Surgeon
|May 11, 2026
Summary
This study identified elevated uric acid, total bilirubin, and decreased platelet count as key risk factors for pyogenic liver abscess progression to sepsis. These markers can help predict patients at high risk for developing sepsis.
Area of Science:
- Hepatology
- Infectious Diseases
- Critical Care Medicine
Background:
- Pyogenic liver abscess (PLA) is a serious condition that can lead to sepsis.
- Identifying risk factors for PLA progression to sepsis is crucial for timely intervention.
Purpose of the Study:
- To investigate risk factors associated with PLA progression to sepsis.
- To evaluate the predictive value of these risk factors.
Main Methods:
- Retrospective analysis of PLA patients from January 2019 to December 2024.
- Multivariate logistic regression to identify independent risk factors.
- Receiver operating characteristic (ROC) curve analysis to assess predictive performance.
Main Results:
- Uric acid (UA), total bilirubin (TBIL), and platelet count (PLT) were identified as independent risk factors.
- Specific thresholds were determined: UA ≥306.5 μmol/L, TBIL ≥26.75 μmol/L, and PLT ≤155 × 10^9/L.
- ROC analysis demonstrated predictive capabilities for these markers.
Conclusions:
- Elevated UA and TBIL, along with decreased PLT, are significant predictors of sepsis progression in PLA patients.
- These laboratory markers and their threshold values can aid in identifying high-risk patients.
- Clinical application of these findings can improve patient management and outcomes.
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