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Updated: May 13, 2026
07:51
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Cardiovascular Comorbidities and Risk in Hidradenitis Suppurativa: A Systematic Review and Meta-analysis
Sophia A Mense1, Theresa Hopkins2, Raj Chovatiya2,3
1Rush University Medical College, Chicago, IL, USA.
The British Journal of Dermatology
|May 11, 2026
Summary
Hidradenitis suppurativa (HS) significantly increases the risk of cardiovascular diseases. Patients with HS face a higher likelihood of developing conditions like heart disease and stroke, underscoring the need for proactive cardiovascular risk assessment.
Area of Science:
- Dermatology and Cardiology
- Epidemiology
- Systematic Review & Meta-Analysis
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- HS is linked to cardiometabolic issues, but cardiovascular risk data is inconsistent.
Purpose of the Study:
- Quantify cardiovascular comorbidities in HS patients.
- Evaluate the association between HS and cardiovascular outcomes compared to controls.
Main Methods:
- Systematic review and meta-analysis of 25 studies (373,689 individuals).
- Searched CINAHL, Cochrane, Embase, PubMed, Scopus.
- Used random-effects meta-analyses and assessed risk of bias and certainty of evidence.
Main Results:
- Hypertension is the most common comorbidity (~25% of HS patients).
- HS is associated with 1.3- to 1.8-fold increased risk of ischemic heart disease, myocardial infarction, heart failure, and mortality.
- Low certainty of evidence due to observational study designs.
Conclusions:
- HS presents a substantial burden of cardiovascular comorbidities and elevated risk for major cardiovascular outcomes.
- Cardiovascular risk assessment is recommended for HS management.
- Need for prospective studies with standardized definitions and confounder adjustment.
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