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Related Experiment Video

Updated: May 13, 2026

Pupillometry to Assess Auditory Sensation in Guinea Pigs
09:25

Pupillometry to Assess Auditory Sensation in Guinea Pigs

Published on: January 6, 2023

Auditory brainstem response in pigs: normative data and insights from TPC2 knockout models.

Sheila Templado1, Maite Almela-Rojo2, Maria Dolores Barceló3

  • 1Clínica Templado. Otorrinolaringología y Audiología Avanzada. 30005 Murcia, Spain.

Hearing Research
|May 11, 2026
PubMed
Summary

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This study establishes normative auditory brainstem response (ABR) values in pigs, crucial for hearing research. No significant ABR differences were found across genotypes or sex, supporting pigs as robust auditory models.

Area of Science:

  • Animal Models
  • Auditory Neuroscience
  • Translational Research

Background:

  • Pigs are valuable translational models for human auditory research due to physiological similarities.
  • Limited characterization of normative auditory brainstem response (ABR) parameters in pigs hinders their use in hearing studies.

Purpose of the Study:

  • Establish reference ABR values across stimulus intensities in pigs.
  • Assess the influence of genotype (including TPC2 knockout), age, and sex on ABR parameters.
  • Validate pigs as a model for auditory research and genetic studies of hearing loss.

Main Methods:

  • Auditory brainstem response (ABR) recordings from 42 pigs (wild-type, heterozygous, TPC2KO).
  • Click stimuli presented at varying intensities (90-10 dB nHL) under anesthesia.
Keywords:
Auditory brainstem responseHearing thresholdNormative dataPig modelTPC2 gene

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Last Updated: May 13, 2026

Pupillometry to Assess Auditory Sensation in Guinea Pigs
09:25

Pupillometry to Assess Auditory Sensation in Guinea Pigs

Published on: January 6, 2023

Noninvasive, In-pen Approach Test for Laboratory-housed Pigs
06:30

Noninvasive, In-pen Approach Test for Laboratory-housed Pigs

Published on: June 5, 2019

  • Analysis of wave latencies, amplitudes, interpeak intervals, and thresholds using statistical models and machine learning.

    • Main Results:

    • ABR peak detection and amplitude decreased with lower stimulus intensities; latencies increased.
    • Wave V was detectable at all intensities, with a mean threshold of 33.6 dB nHL.
    • Age was the most significant factor influencing ABR variability; no significant differences across genotypes or sex were observed.

    Conclusions:

    • Normative ABR reference values for pigs were established across stimulus intensities.
    • No detectable click-evoked ABR alterations were found in TPC2 knockout pigs.
    • These findings support the utility of pigs in auditory research and genetic studies of hearing impairment.