LASP1 facilitates bladder cancer progression through binding and downregulating MYH9 to inhibit mitochondrial
Ke Wang1, Zewei Hu1, Yihao Zhu2
1Department of Urology, The First Hospital of China Medical University, Shenyang, 110001, China.
International Journal of Biological Macromolecules
|May 11, 2026
Summary
LIM and SH3 protein 1 (LASP1) promotes bladder cancer progression by interacting with MYH9. This interaction prevents apoptosis and enhances tumor growth and metastasis, offering a potential therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- The role of LIM and SH3 protein 1 (LASP1) in bladder cancer is not well understood.
- LASP1 is implicated in tumorigenesis and metastasis in various cancers.
Purpose of the Study:
- To investigate the function and mechanism of LASP1 in bladder cancer.
- To identify LASP1-interacting proteins and their role in bladder cancer progression.
Main Methods:
- Analysis of LASP1 expression in bladder cancer tissues.
- Co-immunoprecipitation and mass spectrometry to identify binding partners.
- Functional assays (in vitro and in vivo) to assess the impact of LASP1-MYH9 interaction on cell behavior and tumor growth.
Main Results:
- LASP1 is significantly upregulated in bladder cancer and associated with poor prognosis.
- MYH9 was identified as a direct binding partner of LASP1, with interaction mediated by specific protein domains.
- LASP1 regulates MYH9 to maintain mitochondrial integrity and function, inhibiting apoptosis and promoting proliferation and migration.
- The LASP1-MYH9 axis was shown to enhance bladder cancer growth and metastasis in both in vitro and in vivo models.
Conclusions:
- LASP1 promotes bladder cancer progression by interacting with MYH9, inhibiting mitochondria-mediated apoptosis.
- The LASP1-MYH9 axis represents a potential therapeutic target for bladder cancer treatment.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:31The Intrinsic Apoptotic Pathway
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...