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A Functional TNFRSF13B Variant Disrupts B-Cell Enhancer Activity and Increases Susceptibility to EBV-Negative
Julia Nakano1, Nguyen Hoang Viet2, Hoang Thao Giang Nguyen1
1Faculty of Health Sciences, Kanazawa University, Kanazawa, Japan.
Gene
|May 11, 2026
Summary
A specific gene variant (rs4792800 GG genotype) in TNFRSF13B increases lymphoma risk, particularly for diffuse large B-cell lymphoma and EBV-negative cases. This suggests inherited immune regulation defects contribute to cancer development.
Area of Science:
- Genetics
- Immunology
- Oncology
Background:
- The TNFRSF13B gene encodes TACI, crucial for B-cell survival and immune homeostasis.
- Gene variants are linked to immunodeficiency, but their role in lymphoma is not fully understood.
Purpose of the Study:
- To investigate the association between the TNFRSF13B polymorphism rs4792800 (A>G) and lymphoma risk.
Main Methods:
- A hospital-based case-control study with 200 lymphoma patients and 119 healthy controls.
- Genotyping using allele-specific PCR and logistic regression analysis.
- In silico analysis to assess regulatory potential and transcription factor binding.
Main Results:
- The G allele was significantly more common in lymphoma cases (51.8%) than controls (42.0%).
- The rs4792800 GG genotype showed a 1.9-fold increased lymphoma risk, especially in diffuse large B-cell lymphoma (OR=2.32) and EBV-negative disease (OR=1.99).
- In silico analysis indicated the G allele disrupts EBF1 binding and enhances PAX5 binding, potentially reducing TNFRSF13B expression.
Conclusions:
- The rs4792800 GG genotype is linked to a higher risk of developing lymphoma.
- Inherited variations affecting TACI-mediated immune surveillance may contribute to lymphomagenesis independently of viral factors.
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