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O-GlcNAcylation of KAT2A Enhances Bladder Cancer Proliferation by Inhibiting the KAT2A-TRIM22 Interaction

Wenjie Yang1, Zhaoheng Jin1, Ziyi Li1

  • 1Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cancer Science
|May 11, 2026
PubMed
Summary

O-GlcNAcylation stabilizes Lysine acetyltransferase 2A (KAT2A) in bladder cancer (BLCA) by preventing its degradation. This post-translational modification promotes tumor growth by upregulating oncogenes, suggesting KAT2A O-GlcNAcylation as a therapeutic target for BLCA.

Keywords:
KAT2AO‐GlcNAcylationbladder cancerproliferationubiquitination

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