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Updated: May 13, 2026

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Risk factors for recurrence following robot-assisted laparoscopic partial nephrectomy (RAPN): a single-center

Masaharu Oki1, Kojiro Ohba2, Tsuyoshi Matsuda1

  • 1Department of Urology and Renal Transplantation, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, Japan.

BMC Urology
|May 12, 2026
PubMed
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This summary is machine-generated.

Robot-assisted partial nephrectomy (RAPN) for renal cell carcinoma shows a 5.3% recurrence rate. Advanced pT stage and Fuhrman grade are potential risk factors, while positive surgical margins were not significantly associated with recurrence.

Area of Science:

  • Urology
  • Oncology
  • Surgical Innovation

Background:

  • Robot-assisted partial nephrectomy (RAPN) is increasingly used for renal cell carcinoma (RCC).
  • Identifying recurrence risk factors after RAPN is crucial for patient management.
  • Existing data on recurrence rates and associated factors post-RAPN is limited.

Purpose of the Study:

  • To investigate the recurrence rate following RAPN for RCC.
  • To identify significant risk factors associated with recurrence after RAPN.
  • To evaluate the impact of pathological tumor stage and Fuhrman grade on recurrence-free survival.

Main Methods:

  • Retrospective analysis of 205 patients with RCC who underwent RAPN between 2016 and 2024.
  • Evaluation of recurrence rates, including local and non-local recurrences.
Keywords:
RecurrenceRenal cell carcinomaRisk factorRobot-assisted partial nephrectomy

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  • Statistical analysis, including Cox regression, to identify factors associated with recurrence-free survival.

    • Main Results:

    • The overall postoperative recurrence rate was 5.3% (11 out of 205 patients).
    • Pathological tumor (pT) stage ≥3a and Fuhrman grade ≥3 were significantly associated with increased recurrence risk (HR: 8.2 and 9.2, respectively).
    • Positive surgical margins did not show a significant association with recurrence in this cohort.

    Conclusions:

    • pT stage ≥3a and Fuhrman grade ≥3 are potential indicators of recurrence risk after RAPN for RCC.
    • Positive surgical margins may not be a significant predictor of recurrence in this context.
    • Further validation in larger cohorts is recommended due to the limited number of recurrence events.