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Updated: May 13, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Multilayer Detachable Microneedles for Therapeutic and Collaborative Digital PCR Monitoring.

Yun Cheng^1,2, Xi Luan², Rokshana Parvin²

¹Key Laboratory of Structural Malformations in Children of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Advanced Healthcare Materials

|May 12, 2026

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This study introduces a microneedle system for skin cancer theranostics, enabling controlled drug delivery and real-time monitoring of cancer markers via droplet-based PCR.

Area of Science:

Biomedical Engineering
Nanotechnology
Dermatology

Background:

Microneedle (MN) technology offers potential for skin cancer treatment but faces challenges in integrating theranostic capabilities and personalized sensing.
Current MN systems require advanced trace analysis techniques due to limited sample volumes.

Purpose of the Study:

To develop a versatile, multilayer, detachable MN system for simultaneous photocontrolled drug delivery and real-time monitoring of skin cancer biomarkers.
To demonstrate the system's efficacy in enhancing therapeutic outcomes and enabling personalized diagnostics for melanoma.

Main Methods:

Fabrication of a multilayer MN with poly (ethylene glycol) diacrylate, gelatin methacryloyl (loaded with Vemurafenib and black phosphorus), and polyvinyl alcohol layers.
Photothermal drug release triggered by black phosphorus and interstitial fluid extraction facilitated by MN swelling.

Keywords:

digital PCR digital PLA drug delivery microfluidics microneedles therapeutic collaborative monitoring

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Last Updated: May 13, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Droplet-based PCR (dPCR) for gene analysis (MCAM, BRAF V600E) and digital proximity ligation assay for protein marker detection (IL-6, VEGF, Ki-67).

Main Results:

Achieved 78% drug release within 24 hours via light-responsive photothermal properties.
Successfully extracted ~26 µL of interstitial fluid within 10 minutes.
Demonstrated enhanced therapeutic efficacy and minimized toxicity in vitro and in vivo melanoma models.
Achieved low detection limits for gene markers (223 copies/µL) and protein markers (0.64 pg/mL).

Conclusions:

The developed MN system provides a preclinical proof-of-concept for minimally invasive theranostics in superficial tumors.
The system effectively integrates drug delivery, monitoring, and personalized sensing for enhanced cancer treatment.
This biosystem showcases adaptability to pathophysiological environments for advanced biomedical applications.