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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Published on: April 13, 2010

Rheumatoid arthritis and airway hyperresponsiveness: A GWAS-based mendelian randomization study.

Hengxiang Shu1, Yu Wang1, Ruoyi Shen2

  • 1Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.

Medicine
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

This study found that genetic susceptibility to rheumatoid arthritis (RA) causally increases the risk of developing asthma and bronchitis. However, RA showed no causal link to allergic rhinitis or chronic obstructive pulmonary disease (COPD).

Keywords:
AHDsGWAS analysisMendelian randomizationcausal relationshiprheumatoid arthritis

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Last Updated: May 13, 2026

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Area of Science:

  • Rheumatology and Respiratory Medicine
  • Genetic Epidemiology
  • Immunology

Background:

  • Observational studies suggest a link between rheumatoid arthritis (RA) and airway hyperresponsiveness diseases (AHDs).
  • The causal nature of the association between RA and AHDs remains unclear.
  • Investigating this causal relationship is crucial for understanding disease pathogenesis and developing targeted interventions.

Purpose of the Study:

  • To investigate the causal relationship between rheumatoid arthritis (RA) and various airway hyperresponsiveness diseases (AHDs).
  • To determine if genetic predisposition to RA influences the risk of asthma, bronchitis, allergic rhinitis, and COPD.
  • To utilize robust statistical methods to establish causality.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) analysis using publicly available genome-wide association study (GWAS) summary statistics.
  • Selected single nucleotide polymorphisms (SNPs) associated with RA (overall, seropositive, seronegative) and AHDs (asthma, bronchitis, allergic rhinitis, COPD) as instrumental variables.
  • Utilized inverse variance weighted (IVW) as the primary method, supplemented by weighted median, MR-Egger regression, and MR-PRESSO for sensitivity analyses and quality control.

Main Results:

  • Found a significant causal effect of genetically determined RA on an increased risk of asthma (OR=1.007, P<0.001) and bronchitis (OR=1.001, P=0.022).
  • Seropositive RA showed a causal association with asthma (OR=1.007, P=0.037) and bronchitis (OR=1.001, P<0.001).
  • No significant causal relationship was identified between RA and allergic rhinitis or COPD. Sensitivity analyses confirmed the robustness of findings, showing no significant pleiotropy or heterogeneity.

Conclusions:

  • Genetic susceptibility to rheumatoid arthritis is causally associated with an increased risk of developing asthma and bronchitis.
  • The study provides evidence supporting a causal link between RA and these respiratory conditions, distinct from observational associations.
  • No causal association was found between RA and allergic rhinitis or COPD, suggesting distinct etiological pathways for these conditions.