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Related Experiment Video

Updated: May 13, 2026

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Achilles Tendon Injury Alters Lymphatic and Venous Clearance in Rats.

Jarod M Forer1,2, Kaitlyn A Link1, Bella Yannello1

  • 1Department of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon, USA.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|May 12, 2026
PubMed
Summary

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Achilles tendon rupture alters microcirculatory transport, affecting lymphatic and venous clearance. These changes in fluid dynamics offer potential targets for treating tendon injuries.

Area of Science:

  • Musculoskeletal biology
  • Vascular biology
  • Regenerative medicine

Background:

  • Achilles tendon injuries are common, impacting musculoskeletal health.
  • Tendon homeostasis relies on microcirculation, including lymphatic drainage, but pathways are poorly understood.
  • Interstitial fluid accumulation occurs in diseased tendons, suggesting impaired clearance.

Purpose of the Study:

  • To characterize lymphatic and venous clearance pathways in rat Achilles tendons after surgical rupture.
  • To investigate the impact of tendon rupture on size-specific tracer clearance rates.
  • To correlate microcirculatory changes with histological and functional outcomes post-injury.

Main Methods:

  • Used size-specific near-infrared tracers to assess lymphatic and venous clearance in naïve and surgically ruptured rat Achilles tendons.
Keywords:
Achilles tendon injuryfunction and pain assessmentslymphatic clearancenear‐infrared tracer imagingtendon injury microcirculation

Related Experiment Videos

Last Updated: May 13, 2026

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

  • Quantified tracer clearance rates and analyzed histological changes (tendon sheath and core).
  • Assessed pain (tactile allodynia), limb function (dynamic weight bearing), and mechanical properties (tensile testing).

    • Main Results:

    • In naïve tendons, venous clearance exceeded lymphatic clearance, dependent on tracer size.
    • Tendon rupture altered lymphatic clearance rates (increased at 2 weeks, decreased at 8 weeks) and elevated venous clearance rates (at 4 and 8 weeks).
    • Histology revealed structural disruption; functional deficits (pain, limb loading, stiffness) showed varying recovery timelines.

    Conclusions:

    • Surgical Achilles tendon rupture significantly disrupts microcirculatory clearance pathways.
    • Altered fluid dynamics and impaired lymphatic function are key features of tendon injury.
    • Targeting microcirculation and fluid accumulation presents a promising therapeutic strategy for tendon repair.