Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxicity during induction of pulsed versus continuous prednisolone in children with acute lymphoblastic leukaemia: a multi-centre, open label, randomised, phase 3 trial from India (2016-2022).

The Lancet regional health. Southeast Asia·2026
Same author

A global survey of blood transfusion practices for patients with sickle cell disease.

Transfusion·2026
Same author

First Report of <i>MYH9</i> E1841K Variant in an Indian Family: A Case of Familial Macrothrombocytopenia and Review of Literature.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

A Case of B-lymphoblastic Lymphoma with <i>MYC</i> Rearrangement Mimicking Burkitt Lymphoma.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

TP53 isoform dysregulation in pediatric B-ALL: identifying markers of favorable prognosis and relapse-associated dynamic.

Molecular biology reports·2026
Same author

Variation in Chronic Automated Red Cell Exchange Practices for Sickle Cell Disease: Insights Into Isovolemic Hemodilution Use.

Journal of clinical apheresis·2026

Related Experiment Video

Updated: May 13, 2026

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
08:32

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

Published on: August 9, 2022

Simple Interventions Can Improve Access to Autologous Stem Cell Transplant in Low- and Lower-Middle-Income Countries

Deepak Bansal1, Swati Chandel1, Rekha Hans2

  • 1Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pediatric Blood & Cancer
|May 12, 2026
PubMed
Summary

Resource-adapted autologous stem cell transplant (ASCT) for high-risk neuroblastoma was feasible in a low-resource setting. However, these adapted strategies did not significantly improve survival outcomes compared to historical non-transplant data.

Keywords:
LMICautologous stem cell rescuecryopreservationneuroblastomaplerixaforsurvival

More Related Videos

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Related Experiment Videos

Last Updated: May 13, 2026

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
08:32

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

Published on: August 9, 2022

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Transplant Medicine

Background:

  • High-risk neuroblastoma treatment often requires autologous stem cell transplant (ASCT).
  • Access to ASCT is limited in lower-middle-income countries due to resource constraints.
  • This study aimed to adapt ASCT protocols for a public hospital setting.

Purpose of the Study:

  • To evaluate the feasibility and safety of resource-adapted ASCT for high-risk neuroblastoma.
  • To enhance ASCT accessibility in a public hospital within a lower-middle-income country.
  • To compare outcomes with historical non-transplant data.

Main Methods:

  • An ambispective, observational study analyzed data from 73 patients over 12 years.
  • Adaptations included performing ASCT in general wards, short-term stem cell storage, and modified prophylaxis.
  • Resource-saving measures like minimizing venipunctures and avoiding routine transfusions were implemented.

Main Results:

  • The busulfan+melphalan regimen was used in 84.9% of patients.
  • Median hospital stay was 20 days, with acceptable neutrophil and platelet counts at discharge.
  • Survival rates (5-year OS 34.6%, EFS 27%) were comparable to a historical non-transplant cohort.

Conclusions:

  • Resource-adapted ASCT for high-risk neuroblastoma is feasible in low-resource settings.
  • The implemented strategies did not lead to a significant improvement in survival outcomes.
  • Further research is needed to optimize ASCT protocols for improved efficacy in resource-limited environments.