Recalibration and external validation of vascular risk calculators for multiple sclerosis: A population-based study

Raffaele Palladino1, Ruth Ann Marrie2, Giuseppina Affinito3

  • 1Department of Primary Care and Public Health, School of Public Health, Imperial College of London, London, UK; Department of Public Health, Federico II University, Naples, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 12, 2026
PubMed
Summary

Vascular risk calculators (VRCs) underestimate macrovascular disease risk in people with multiple sclerosis (MS). Recalibration of the FRS-BMI model improved accuracy, but MS-specific models are needed.

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