Related Experiment Video
Updated: May 13, 2026
Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
Published on: March 31, 2023
Floppy rabbit syndrome: A retrospective study of clinicopathological data and outcomes
Julia Polovitzer-Warum1, Joana Glöckel1, Akos Pakozdy1
1Clinic for Small Animals, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Background:
Floppy rabbit syndrome (FRS) is known as an idiopathic neurological condition with a peracute onset of tetraparesis. While there are several anecdotal reports mentioning this phenomenon, scientific literature on this subject is scarce. The aim of this study was to assess clinical and clinicopathological data as well as the outcome of patients with FRS.
Methods:
This retrospective study included pet rabbits that presented with a peracute progressive symmetric lower motor neuron tetraparesis characterised by generalised weakness in all four limbs and decreased muscle tone and spinal reflexes. History, clinical signs, laboratory results, treatment and outcome were analysed.
Results:
The data revealed nine rabbits with non-ambulatory tetraparesis resembling FRS. Otherwise, the rabbits presented clinically unremarkably. All the animals showed significantly increased serum creatine kinase (CK) concentrations. Eight out of nine rabbits fully recovered within a short period.
Limitations:
The study is limited by the small number of patients and the absence of muscle biopsy results and electromyography.
Conclusion:
FRS can be clearly diagnosed due to its typical consistent clinical presentation and neurological examination. Clinical pathology, including the determination of serum CK concentrations, may aid in differentiating FRS from other diseases. FRS is typically self-limiting idiopathic neuromuscular disease that does not require specific treatment; therefore, euthanasia should be avoided.
