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In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Four-Decade (1980-2023) Surface Ozone Concentrations across the Contiguous United States: Fine-Resolution Estimates
Riyang Liu1,2, Lingzhi Chu1,2, Nicole C Deziel1
1Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06510, United States.
High-resolution historical ozone (O3) data reveals rural areas face higher exposure. Despite decreasing trends, health burdens increased due to population changes, impacting air quality policy.
Area of Science:
- Environmental Science
- Public Health
- Data Science
Background:
- Ambient ozone (O3) exposure presents significant health risks.
- Limited high-resolution historical O3 data hinders comprehensive health burden evaluation.
Purpose of the Study:
- To develop a high-resolution historical surface O3 dataset for the contiguous US.
- To enable detailed epidemiological studies and inform air quality policy.
Main Methods:
- Developed a Light Gradient Boosting Machine framework with geophysical data and k-fold nearest neighbor distance matching cross-validation.
- Generated daily maximum 8-h average O3 concentrations at ~1 km resolution from 1980-2023.
- Achieved strong predictive performance with cross-validation R2 values ranging from 0.53 to 0.94.
Main Results:
- Identified higher average O3 exposure in rural areas and more high-O3 days in urban areas.
- Observed slower O3 decreasing trends in most urban regions.
- Despite decreased O3 levels, health burdens increased by 25% (short-term) and 18% (long-term) from 1990-2023 due to population growth and aging.
Conclusions:
- The 44-year O3 dataset is the first comprehensive reconstruction at this resolution.
- Findings support in-depth life-course epidemiological studies.
- Data can inform evidence-based air quality policy decisions.
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