Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Collection I01:30

Data Collection I

Data collection gathers information needed to make accurate judgments about a patient's present condition. During a health history interview, subjective data is collected from the patient, their caregivers, or family members, and objective data is collected through observations and physical assessment. Patients are the primary source of subjective data. Thus information gathered from patients through interviews, observations, and physical examination is primary data. Secondary sources of data...
Methods of Documentation V: CBE01:23

Methods of Documentation V: CBE

Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonization of measurement units: mission impossible or ethical imperative?

Clinical chemistry and laboratory medicine·2026
Same author

The value-based score in laboratory medicine: results of a European pilot study.

Clinical chemistry and laboratory medicine·2026
Same author

Characterizing variation in laboratory medicine data: a comparative analysis of standard deviation and coefficient of variation.

Clinical chemistry and laboratory medicine·2026
Same author

Lot-to-lot variability of a high-sensitivity cardiac troponin I assay: clinical implications.

Clinical chemistry and laboratory medicine·2026
Same author

EFLM position statement on the proposed 2025/0404(COD) IVDR Amendment of Article 5.5.

Clinical chemistry and laboratory medicine·2026
Same author

Albumin-adjusted ("corrected") calcium should no longer be reported: a position statement from the Joint IOF Working Group and IFCC Committee on Bone Metabolism and EFLM Committee on CKD.

Clinical chemistry and laboratory medicine·2026

Related Experiment Video

Updated: May 13, 2026

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

The complete blood count: data or clinical information?

Mario Plebani1, Mauro Buttarello2, Sofia Chiatamone Ranieri3

  • 1Department of Medicine-DIMED, University of Padova, Padova, Italy.

Clinical Chemistry and Laboratory Medicine
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

Harmonization in laboratory medicine is crucial for patient safety, yet gaps persist in test requesting, analysis, and interpretation. The complete blood count (CBC) exemplifies these issues, highlighting the need for better clinical context and collaboration.

Keywords:
appropriatenesscomplete blood countharmonizationlaboratory reporttest requestvalue-based laboratory medicine

More Related Videos

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

Related Experiment Videos

Last Updated: May 13, 2026

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

Area of Science:

  • Laboratory Medicine
  • Clinical Pathology
  • Medical Diagnostics

Background:

  • Harmonization in laboratory medicine is essential for data interchangeability, user clarity, and patient safety.
  • Significant harmonization gaps exist across the total testing process, including test ordering, analytical methods, reporting units, and result interpretation.
  • The complete blood count (CBC) serves as a key example of persistent harmonization challenges and their clinical impact.

Purpose of the Study:

  • To highlight the critical need for comprehensive harmonization in laboratory medicine, extending beyond analytical standardization.
  • To emphasize the importance of aligning test requesting, reporting, and interpretation with clinical context, using CBC as a model.
  • To advocate for a shift towards Value-Based Laboratory Medicine, focusing on actionable, clinically meaningful results.

Main Methods:

  • Review of current literature and influential publications in high-impact medical journals (e.g., Nature, JAMA).
  • Analysis of harmonization issues related to the complete blood count (CBC) parameters and interpretation.
  • Conceptual framework development for improving laboratory medicine practice through collaboration.

Main Results:

  • Persistent lack of harmonization in laboratory medicine, particularly evident in the CBC test.
  • Identified issues include heterogeneity in CBC parameters reported and the need for personalized reference intervals.
  • Harmonization efforts must encompass test requesting, analytical comparability, and clinical interpretation, not just standardization.

Conclusions:

  • Harmonization in laboratory medicine requires a holistic approach addressing the entire testing pathway.
  • The CBC exemplifies the need for improved interpretative criteria and standardized reporting to reduce clinical uncertainty.
  • Enhanced collaboration between laboratory professionals and clinicians is vital for delivering value-based laboratory medicine and improving patient outcomes.